Hypothesis: What is the Best We Can Do with Hydroxychloroquine for COVID-19?
Identifieur interne : 001B07 ( Main/Exploration ); précédent : 001B06; suivant : 001B08Hypothesis: What is the Best We Can Do with Hydroxychloroquine for COVID-19?
Auteurs : Shuncong Wang [Belgique] ; Stefaan Mulier [Belgique] ; Charles Jonscher [États-Unis] ; Sheng Ye [États-Unis] ; Lei Chen [Belgique] ; Yuanbo Feng [Belgique] ; Yue Li [République populaire de Chine] ; Yicheng Ni [Belgique]Source :
- Clinical epidemiology [ 1179-1349 ] ; 2020.
Abstract
There are widespread anecdotal reports of seemingly successful treatment among the early (three to seven days from symptoms) stage coronavirus disease 2019 (COVID-19) patients with the drug hydroxychloroquine (HCQ), and randomized placebo-controlled trials of HCQ in outpatient settings are underway. In this note, we (1) report observational evidence and present scientific reasoning as to why early treatment with HCQ may succeed while treatment later in the disease progression is likely to fail and (2) hypothesize a public health regime under which HCQ may be used to mitigate the impact of the current pandemic.
DOI: 10.2147/CLEP.S277889
PubMed: 33116907
PubMed Central: PMC7585824
Affiliations:
- Belgique, République populaire de Chine, États-Unis
- New Jersey, Région de Bruxelles-Capitale, Washington (État)
- Bruxelles, Seattle
- Université de Washington
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xml:lang="fr">Belgique</country><wicri:regionArea>Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery, Delta Hospital, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Surgery, Delta Hospital, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Jonscher, Charles" sort="Jonscher, Charles" uniqKey="Jonscher C" first="Charles" last="Jonscher">Charles Jonscher</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Health Metrics & Evaluation, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Health Metrics & Evaluation, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Ye, Sheng" sort="Ye, Sheng" uniqKey="Ye S" first="Sheng" last="Ye">Sheng Ye</name><affiliation wicri:level="2"><nlm:affiliation>Primary Care NJ, Englewood, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Primary Care NJ, Englewood, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Chen, Lei" sort="Chen, Lei" uniqKey="Chen L" first="Lei" last="Chen">Lei Chen</name><affiliation wicri:level="1"><nlm:affiliation>Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Feng, Yuanbo" sort="Feng, Yuanbo" uniqKey="Feng Y" first="Yuanbo" last="Feng">Yuanbo Feng</name><affiliation wicri:level="1"><nlm:affiliation>Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yue" sort="Li, Yue" uniqKey="Li Y" first="Yue" last="Li">Yue Li</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318</wicri:regionArea><wicri:noRegion>Shanghai 201318</wicri:noRegion></affiliation></author><author><name sortKey="Ni, Yicheng" sort="Ni, Yicheng" uniqKey="Ni Y" first="Yicheng" last="Ni">Yicheng Ni</name><affiliation wicri:level="1"><nlm:affiliation>Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author></analytic><series><title level="j">Clinical epidemiology</title><idno type="ISSN">1179-1349</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are widespread anecdotal reports of seemingly successful treatment among the early (three to seven days from symptoms) stage coronavirus disease 2019 (COVID-19) patients with the drug hydroxychloroquine (HCQ), and randomized placebo-controlled trials of HCQ in outpatient settings are underway. In this note, we (1) report observational evidence and present scientific reasoning as to why early treatment with HCQ may succeed while treatment later in the disease progression is likely to fail and (2) hypothesize a public health regime under which HCQ may be used to mitigate the impact of the current pandemic.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33116907</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>30</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1179-1349</ISSN><JournalIssue CitedMedium="Print"><Volume>12</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Clinical epidemiology</Title><ISOAbbreviation>Clin Epidemiol</ISOAbbreviation></Journal><ArticleTitle>Hypothesis: What is the Best We Can Do with Hydroxychloroquine for COVID-19?</ArticleTitle><Pagination><MedlinePgn>1139-1144</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2147/CLEP.S277889</ELocationID><Abstract><AbstractText>There are widespread anecdotal reports of seemingly successful treatment among the early (three to seven days from symptoms) stage coronavirus disease 2019 (COVID-19) patients with the drug hydroxychloroquine (HCQ), and randomized placebo-controlled trials of HCQ in outpatient settings are underway. In this note, we (1) report observational evidence and present scientific reasoning as to why early treatment with HCQ may succeed while treatment later in the disease progression is likely to fail and (2) hypothesize a public health regime under which HCQ may be used to mitigate the impact of the current pandemic.</AbstractText><CopyrightInformation>© 2020 Wang et al.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Wang</LastName><ForeName>Shuncong</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Mulier</LastName><ForeName>Stefaan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Surgery, Delta Hospital, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jonscher</LastName><ForeName>Charles</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0003-2510-2663</Identifier><AffiliationInfo><Affiliation>Institute for Health Metrics & Evaluation, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ye</LastName><ForeName>Sheng</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Primary Care NJ, Englewood, NJ, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Lei</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Yuanbo</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yue</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ni</LastName><ForeName>Yicheng</ForeName><Initials>Y</Initials><Identifier Source="ORCID">0000-0002-8553-7565</Identifier><AffiliationInfo><Affiliation>Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven, Belgium.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>10</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>New Zealand</Country><MedlineTA>Clin Epidemiol</MedlineTA><NlmUniqueID>101531700</NlmUniqueID><ISSNLinking>1179-1349</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">early treatment</Keyword><Keyword MajorTopicYN="N">hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">lockdown</Keyword><Keyword MajorTopicYN="N">pandemic</Keyword></KeywordList><CoiStatement>The authors report no conflicts of interest in this work.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>08</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>09</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>10</Month><Day>29</Day><Hour>5</Hour><Minute>49</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>10</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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